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== | == June Meeting: Prof Stephen Devereux, ''CAR(T)s, BiTes, checkpoints and weaponised antibodies: How immunology is transforming the treatment of blood cancer.'' == | ||
''' | '''June 21st''' | ||
Every year over 30,000 people in the UK are diagnosed with blood cancer and there are more than 12,000 deaths making it the 5th most common cancer overall and the 3rd commonest cause of cancer death. In this talk I will describe how the treatment of blood cancer has evolved over the last 50 years, from repurposed chemical weapons to precision medicines designed to target abnormal pathways and cells. I will pay particular attention to treatments that harness the immune system, as this is an area of particular progress that has the potential to transform the outlook for patients. These exciting advances are, however, accompanied by new challenges. Existing drug development, evaluation and regulatory pathways are relatively slow and this, combined with funding constraints, can delay introduction into clinical practice. New thinking (and money) is going to be required to solve these problems. | |||
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Paul Veys collects immune system cells from the patient, modifies them to help to recognize his cancer cells. The modified cells, cultured in the lab, are then injected back into the patient. This allows the patients own immune system to recognize the cancer cells that were previously invisible to it and kill them. The advantage of this treatment is that the cells become part of the body's own immune system and provide indefinite protection against recurrence of the disease. | Paul Veys collects immune system cells from the patient, modifies them to help to recognize his cancer cells. The modified cells, cultured in the lab, are then injected back into the patient. This allows the patients own immune system to recognize the cancer cells that were previously invisible to it and kill them. The advantage of this treatment is that the cells become part of the body's own immune system and provide indefinite protection against recurrence of the disease. | ||
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T-cells are a key component of our immune system that fights off infection, and indeed any 'foreign' protein that our bodies are exposed to. Cancer cells evade the attention of our immune system. By using gene editing techniques it is possible to program T cells to recognize and eliminate cancer cells that would otherwise go undetected by our bodies. This is a very promising area of work, although it is still experimental and in early stages. Pioneering work has been done at Great Ormond Street Hospital, and we are delighted to welcome Prof Paul Veys to speak to the meeting of the Reform Club Science Group. | T-cells are a key component of our immune system that fights off infection, and indeed any 'foreign' protein that our bodies are exposed to. Cancer cells evade the attention of our immune system. By using gene editing techniques it is possible to program T cells to recognize and eliminate cancer cells that would otherwise go undetected by our bodies. This is a very promising area of work, although it is still experimental and in early stages. Pioneering work has been done at Great Ormond Street Hospital, and we are delighted to welcome Prof Paul Veys to speak to the meeting of the Reform Club Science Group. | ||
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[[Paul Veys|Read More ...]] | [[Paul Veys|Read More ...]] |
Revision as of 08:43, 31 May 2017
June Meeting: Prof Stephen Devereux, CAR(T)s, BiTes, checkpoints and weaponised antibodies: How immunology is transforming the treatment of blood cancer.
June 21st
Every year over 30,000 people in the UK are diagnosed with blood cancer and there are more than 12,000 deaths making it the 5th most common cancer overall and the 3rd commonest cause of cancer death. In this talk I will describe how the treatment of blood cancer has evolved over the last 50 years, from repurposed chemical weapons to precision medicines designed to target abnormal pathways and cells. I will pay particular attention to treatments that harness the immune system, as this is an area of particular progress that has the potential to transform the outlook for patients. These exciting advances are, however, accompanied by new challenges. Existing drug development, evaluation and regulatory pathways are relatively slow and this, combined with funding constraints, can delay introduction into clinical practice. New thinking (and money) is going to be required to solve these problems.
2017 Programme
Dates for 2017 are as follows (all meeting are on Wednesdays, usually the 3rd one of each month):
Month | Day of Month | Speaker | Title |
---|---|---|---|
February | 15th | Prof Martyn Thomas | Cybersecurity |
March | 15th | Prof Anil Seth | Machine Consciousness |
April | 19th | Prof Peter Wilson | Anti-Microbial Resistance. |
May | 16th, | Dr Giles Yeo | Are your genes to blame if your jeans don't fit? |
June | 21st | Prof Paul Veys | CAR-T Study, Anthony Nolan. |
September | 20th | Dr Paolo Tasca | Bitcoins and the Blockchain |
October | 18th | Prof J A Madrigal | Stem cell therapies. |
November | 22nd [TBC] | Dr Uday Phadke | How to give Tech Businesses Scale |
2018 Programme
Dates for 2018 are as follows (usually 3rd Wed of each month):
Month | Day of Month | Speaker | Title |
---|---|---|---|
February | 21st | ||
March | 14th | ||
April | 25th | ||
May | 23rd | ||
June | 20th | ||
September | 11th | ||
October | 24th | ||
November | 28th |